Biogenesis Inspired Total Synthesis of Natural Products

Grant number: DP110100112 | Funding period: 2011 - 2013

Completed

Abstract

The project will study the chemical synthesis of a number of novel natural products. Most significantly, this project will deliver new methods for organic synthesis of complex molecules. The rewards from the total synthesis of bioactive compounds are enormous for the community and in the education and training of scientists.

Related publications (9)

Scholarly works icon

Total Synthesis of Ustiloxin D Utilizing an Ammonia-Ugi Reaction

AL Brown, QI Churches, CA Hutton

2015-10-16

Total synthesis of the highly functionalized cyclic peptide natural product, ustiloxin D, has been achieved in a convergent manner..

Scholarly works icon

A general method for interconversion of boronic acid protecting groups: Trifluoroborates as common intermediates

QI Churches, JF Hooper, CA Hutton

2015-06-05

We have developed a general protocol for the interconversion of diverse protected boronic acids, via intermediate organotrifluorob..

Scholarly works icon

Synthesis of tryptophans by Lewis acid promoted ring-opening of aziridine-2-carboxylates: Optimization of protecting group and Lewis acid

I Tirotta, NL Fifer, J Eakins, CA Hutton

2013-02-13

The preparation of tryptophan derivatives through the Lewis acid promoted substitution of aziridine carboxylates with indole was f..

Scholarly works icon

Total synthesis of the proposed structure of 8-deshydroxyajudazol a: A modified approach to 2,4-disubstituted oxazoles

S Birkett, D Ganame, BC Hawkins, S Meiries, T Quach, MA Rizzacasa

2013-01-04

The total synthesis of the proposed structure for the minor myxobacterial metabolite 8-deshydroxyajudazol A (3) is described. The ..

Scholarly works icon

Synthetic studies towards the mulberry Diels-Alder adducts: H-bond accelerated cycloadditions of chalcones

S Boonsri, C Gunawan, EH Krenske, MA Rizzacasa

2012-08-14

The methyl ether derivatives 2, 4 and 6 of the mulberry Diels-Alder adducts chalcomoracin (1) and mulberrofuran C (3) and kuwanon ..

Scholarly works icon

Total synthesis of mycocyclosin

JR Cochrane, JM White, U Wille, CA Hutton

2012-05-04

The first total synthesis of mycocyclosin, a diketopiperazine natural product isolated from M. tuberculosis, is described. While d..

Scholarly works icon

10.1016/j.endend.2013.01.001

2000-01-01

The preparation of tryptophan derivatives through the Lewis acid promoted substitution of aziridine carboxylates with indole was f..

Scholarly works icon

10.1016/j.endend.2013.01.003

2000-01-01

The preparation of tryptophan derivatives through the Lewis acid promoted substitution of aziridine carboxylates with indole was f..

Scholarly works icon

10.1016/j.endend.2013.01.005

2000-01-01

The preparation of tryptophan derivatives through the Lewis acid promoted substitution of aziridine carboxylates with indole was f..

University of Melbourne Researchers